The scripts are capable of running in Safe Mode and Safe Mode with Networking
You may wish to utilize this mode if you suspect the system is heavily infected and/or you’re experiencing a lot of lag/CPU spikes while in Normal Mode. It’s almost always faster to start the repair process here, but getting into Safe Mode may seem like a daunting task. But don’t worry, it’s easy! Follow the steps below to enter and exit Safe Mode.
Note: The Task Scheduler cleaning portion of the scan does not work while in this mode. This is the only downside. Task scheduler is a persistence mechanism for most modern malware. The script will still hunt for and delete all other types of traces on the system. It is recommended to rerun the scan when Normal Mode becomes tenable.
Here are the instructions to boot your Windows 10 or Windows 11 computer into Safe Mode with Networking

Type: MSCONFIG
Press Enter key

The System Configuration utility appears:
Click the Boot tab near the top

In the Boot options area located in the bottom left of the window
Click Safe Boot
Click Network
Click OK

You’ll have the option to Restart or Exit without restart. Regardless, the next time you boot your PC, it will be in Safe Mode with Networking
Once you are done with Safe Mode with Networking, use the MSCONFIG once again

Uncheck Safe Boot
Click the General tab in the top left area

Click Normal startup
Click OK
Restart Now or Later